RNA-RNA interactions

Accurate identification of the interactions between RV ssRNAs is computationally challenging due to the sizes of each RNA segment (0.7-3.3 kb), and is practically
impossible without experimentally-derived constraints. Moreover, RNA chaperone-facilitated RNA refolding cannot be modelled using folding energy minimization programs without a detailed knowledge of the structures of each transcript, bound to the respective chaperone. We develop tools to dissect the complexity of RNA-RNA interactions in viruses with segmented RNA genomes.